ea0094p344 | Metabolism, Obesity and Diabetes | SFEBES2023
Curtis Anna
, Jayal Yashoda
, Zhou Zijing
, Akalestou Elina
, S Dhillo Waljit
, G Murphy Kevin
, M Owen Bryn
Defending body weight is a fundamental homeostatic process. Indeed, countless studies have demonstrated weight-maintaining hyperphagia in response to either increased energy expenditure or a reduction in the caloric density of available food. The principal effector of this adaptive food intake is thought to be the adipose tissue-derived hormone, leptin. According to the classical Â’adipostatÂ’ model, the hypoleptinemia resulting from weight loss drives food intake to r...